Pine tsantsa haushi (PBE) kari ne na abinci mai gina jiki wanda aka samo daga cikin dinghy na bishiyar pine. Ya ƙunshi nau'ikan abubuwa masu aiki kamar procyanidins, acid phenolic, da taxifolin waɗanda ke da antioxidant, anti-inflammatory, da sauran kayan kiwon lafiya. Ɗayan yanki na sha'awa a kusa da PBE shine ko yana da wani nau'i na zubar da jini ko magungunan maganin jini.

Hanyoyin dakewar Jini da Bakin ciki

Don fahimtar idan Pure Pine Bark Exfili Foda yana rage jini, yana da mahimmanci na farko don fahimtar yadda clotting ke aiki. Ciwon jini, wanda kuma ake kira coagulation, wani tsari ne mai rikitarwa a cikin jiki wanda ke hana zubar da jini mai yawa lokacin da magudanar jini ya lalace. Ya ƙunshi magudanar ruwa na martanin sinadaran da ke haifar da gudan jini a wurin rauni.

Mahimman abubuwan daskarewa kamar thrombin da fibrin ana kunna su a jere don samar da ragar sunadaran sunadaran da platelet waɗanda ke toshe magudanar jini da suka lalace. Maganganun maganin ƙwanƙwasa jini ko masu kashe jini suna aiki ta hanyar toshe matakai ɗaya ko fiye a cikin wannan kasidar coagulation don hana samuwar gudan jini. Magani na gama gari kamar warfarin yana hana ayyukan abubuwan da suka dogara da Vitamin K.

Abubuwan PBE da Tasirin Rufe

Tunda PBE shine cakuda mahaɗan tsire-tsire daban-daban, masu bincike sun bincika takamaiman abubuwan da zasu iya tasiri aikin clotting:

Procyanidins

Procyanidins sune flavonoids oligomeric waɗanda ke da kashi 60-75% na tsantsar haushin Pine. Nazarin ya nuna procyanidins suna da tasirin antithrombotic ta hanyar hana haɗuwar platelet. Suna kuma tsawaita lokacin zubar jini a cikin nau'ikan dabbobi. Duk da haka, wani binciken ya gano a pine haushi tsantsa opc daidaitattun zuwa 95% procyanidins ba su da wani tasiri akan sifofin coagulation a cikin manya masu lafiya. Har yanzu ana buƙatar ƙarin bincike akan ɓangarorin procyanidin masu tsafta don fayyace tasirin maganin ɗigon jini.

Phenolic acid

Phenolic acid kamar ferulic acid da caffeic acid sun nuna tasirin antithrombotic a wasu nazarin ta hanyar hana ayyukan platelet cyclooxygenase. Amma sauran bincike ya nuna iyakance tasirin acid phenolic akan coagulation da gaurayawan binciken dangane da takamaiman acid. Don haka shaida na yanzu cewa PBE phenolic acid na bakin ciki jini yana da rauni.  

Taxifolin

Taxifolin dihydroflavonol ne da ake samu a wasu nau'in Pine. Ɗaya daga cikin binciken ya ba da rahoton tasirin maganin taxifolin a cikin nau'in dabba, wanda ke da alaƙa da rage matakan abubuwan clotting. Amma wannan fili yana samar da kashi 1-5 ne kawai na yawancin ɓangarorin Pine. Ana buƙatar ƙarin bincike kan ingancin maganin taxifolin na maganin jijiyoyi.

Gabaɗaya, yayin da mahaɗan PBE guda ɗaya ke nuna wasu yuwuwar tasirin zubar jini a cikin lab da nazarin dabbobi, gwajin ɗan adam yana nuna ƙarancin tasiri akan coagulation a cikin ƙarin allurai.

Gwaje-gwajen Clinical na ɗan adam akan Cire Bark na Pine da Coagulation

Gwaje-gwajen asibiti da yawa na ɗan adam yanzu sun bincika ko tsantsa Pine haushi tsantsa foda yana shafar aikin clotting ko haɗarin zubar jini:

Gwajin bazuwar 2006 a cikin manya masu lafiya 40 sun gwada tsantsar haushin pine tare da 40% procyanidins. Bayan ƙarin makonni 3, babu wasu canje-canje a cikin alamun cututtukan thrombosis kamar fibrinogen ko aikin platelet.

Wani bincike na 2015 yana da mata 46 masu ciwon sukari suna ɗaukar 100 MG / rana na cire haushi na Pine don makonni 8. Babu wani tasiri mai mahimmanci akan sigogi na coagulation na yau da kullun kamar lokacin prothrombin (PT) ko lokacin thromboplastin da aka kunna (aPTT).  

Gwaji a cikin masu shan taba 48 sun ba da 200 MG / rana na cire haushi na Pine don makonni 4. Ba a gano canje-canje a cikin PT ko aPTT ba. Fibrinogen da ke kewaya matakan antithrombin III kuma ba su canza ba.

Gwajin makonni 12 da aka yi amfani da 200 MG / rana na cire haushin Pine a cikin masu tsira da ciwon nono 58 akan maganin tamoxifen. Bugu da ƙari, babu wani sakamako na zubar da jini, PBE ba ta da tasiri akan PT ko aPTT tare da placebo. Hakanan bai canza aikin platelet ba.

Gabaɗaya, gwaje-gwajen ɗan adam sun nuna tsantsar haushi na Pine a cikin allurai na yau da kullun ba shi da wani tasiri mai mahimmanci akan coagulation na jini ko haɗarin zubar jini na asibiti, har ma a cikin ƙungiyoyi masu haɗari kamar masu ciwon sukari. Ƙananan sassa na iya samun aiki a keɓe, amma gabaɗayan tsantsa ya bayyana lafiya ga thrombosis. Har yanzu, ana iya ba da garantin taka tsantsan game da haɗa PBE tare da magungunan kashe jini saboda rashin isasshen bincike na hulɗa. Waɗanda ke kan magungunan jini yakamata su tuntuɓi likitan su kafin su ɗauki tsattsauran ƙwayar pine.

Hanyoyi don Rashin Tasirin Jini

Duk da yake mahaɗan PBE guda ɗaya sun nuna wasu yuwuwar anticoagulant a cikin vitro da nazarin dabba, me yasa waɗannan tasirin ba su bayyana a cikin ƙarin allurai na ɗan adam? Wasu dalilai na iya bayyana rashin haɗarin zubar jini mai mahimmanci:

1) Bioavailability - Wasu abubuwan PBE kamar taxifolin suna da ƙarancin bioavailability na baka a cikin ɗan adam wanda ke iyakance tasirin anticoagulant. Matakan Plasma na iya zama ƙasa da ƙasa don hana zubar jini ko da a mafi girman allurai na baki.

2) Abubuwan haɗin gwiwa - PBE kuma ya ƙunshi bitamin K wanda ke kunna abubuwan da ke haifar da clotting. Haɗin magungunan pro- da anticoagulant a cikin PBE na iya daidaita juna.

3) Dose-dogara - Duk wani sakamako na anticoagulant na abubuwan PBE na iya nuna amsawar kashi-kofa. Yawan allurai a cikin gwajin ɗan adam ya zuwa yanzu na iya zama ƙasa da adadin da ake buƙata don canza sigogin jini.

Don haka a taƙaice, iyakancewa a kusa da bioavailability, hulɗar tsakanin mahaɗan masu aiki da yawa, da halayen amsawa na iya yin bayanin dalilin da yasa tsantsar haushi na Pine ke nuna ƙarancin aikin rigakafin cututtukan zuciya.

Pine Bark Cire Sashin La'akari

Yawancin allurai na ƙayyadaddun ƙayyadaddun ƙayyadaddun haushi na Pine sun bambanta daga 50-360 MG kowace rana. Kamar yadda aka rufe, bayanan ɗan adam sun nuna waɗannan ƙarin abubuwan ci ba su da wani tasiri mai mahimmanci akan aikin ƙwanƙwasa ko haɗarin zubar jini. Amma akwai mafi girma allurai lafiya?

Wasu bincike sun gwada tsantsar haushin Pine har zuwa 1000 MG / rana ba tare da al'amuran jini ba. Koyaya, allurai guda ɗaya sama da MG 1000 na ƙayyadaddun tsarin procyanidin na iya ƙara haɗarin zub da jini bisa ƙayyadaddun bayanai. Don haka yana da hankali don guje wa megadoses na tsantsar haushin Pine wanda aka daidaita zuwa babban abun ciki na procyanidin saboda rashin isasshen bincike na aminci a waɗannan iyakar.

Don tsantsar haushin Pine wanda ba daidai ba, allurai guda sama da 600 MG ba a gwada su sosai kuma ba za a iya ba da shawarar ba. Ganin cewa procyanidins na iya haifar da yawancin tasirin anticoagulant, daidaitattun abubuwan cirewa ya kamata a kusanci su da hankali sosai yayin yawan abinci.

A taƙaice, ƙayyadaddun ƙarin allurai na PBE da ke ƙasa da 360 MG suna bayyana lafiya ga ƙullawar jini har ma a cikin ƙungiyoyi masu haɗari dangane da bayanan yanzu. Amma allurai guda sama da 600 MG na yau da kullun na ɓawon pine na yau da kullun ko sama da 1000 MG na ƙayyadaddun ƙa'idodin procyanidin na iya ƙara haɗarin zubar jini a cikin wasu mutane saboda ƙarancin bincike na aminci.

Yawan jama'a a cikin Haɗarin zubar jini

Yayin da tsantsar haushin pine da alama yana da ɗan tasiri akan coagulation na jini ga yawancin manya, wasu manyan haɗarin haɗarin ya kamata su ɗauki ƙarin taka tsantsan:

• Wadanda ke kan magungunan rigakafin jini - PBE na iya ƙara haɗarin zub da jini idan aka haɗa su da kwayoyi kamar warfarin ko heparin, amma binciken hulɗar miyagun ƙwayoyi yana iyakance. Ya kamata a yi amfani da tsantsar haushin Pine a hankali ko kuma a guji su a cikin waɗanda ke kan maganin rigakafin jini sai dai idan likitansu ya amince da su.

• Marasa lafiya da ke fama da matsalar zubar jini - Mutanen da ke fama da cutar haemophilia, cutar von Willebrand, thrombocytopenia, ko wasu cututtukan jini na iya ƙara kamuwa da cutar koda ga ƙananan tasirin jini. Ba a ba da shawarar cire haushin Pine ga waɗannan marasa lafiya ba saboda rashin takamaiman bincike.

• Marasa lafiya kafin a yi wa tiyata - Wasu likitoci sun ba da shawarar dakatar da duk kayan abinci na ganye makonni 1-2 kafin babban tiyata saboda haɗarin rikice-rikicen jini. Babu wani bayani game da zubar jini tare da PBE na musamman, amma dakatar da shi kafin a yi tiyata na iya zama da hankali don yin taka tsantsan.

A taƙaice, tsantsar haushin Pine baya bayyana yana yin bakin jini sosai ga yawancin mutane a ƙarin allurai na yau da kullun bisa ga shaidar yanzu. Amma mutanen da ke kan maganin rigakafi ko kuma tare da ciwon jini ya kamata suyi amfani da hankali tare da PBE saboda rashin isasshen bayanan aminci ga waɗannan ƙungiyoyi masu haɗari. Ana ba da shawarar dakatar da duk kari kafin tiyata ciki har da PBE.

Shin Pycnogenol Shine Sirin Jini?

Duk da yake ɗayan abubuwan da aka haɗa suna nuna wasu ayyuka, Pycnogenol baya yin siriri jini sosai ko kuma yana shafar ƙwanƙwasa a ƙarin allurai na 50-360 MG kowace rana. Gwajin ɗan adam da yawa ba a sami wani canji a cikin sigogin coagulation kamar lokacin prothrombin, aPTT, ko aikin platelet a cikin lafiya da ƙungiyoyi masu haɗari masu ɗaukar Pycnogenol. Ƙananan illolin a cikin vitro mai yuwuwa an shawo kan su ta rashin wadatattun abubuwan rayuwa da abubuwan daidaitawa. Yawan allurai na iya haifar da haɗari mara tabbas.

Shin Bawon Pine Yana Haɓaka Ruwan Jini?

Wasu bincike sun nuna cewa Pycnogenol na iya inganta haɓakar wurare dabam dabam. Ƙananan gwaje-gwaje sun ba da rahoton Pycnogenol ƙara yawan vasodilation, aikin endothelial, da microcirculation, mai yiwuwa ta hanyoyin nitric oxide. An lura da ingantaccen kwararar jini a ƙananan gaɓoɓin masu ciwon sukari da nama masu ƙarfi. Amma nazarin meta-bincike na baya-bayan nan ya kammala girma, ana buƙatar karatu mai inganci don tabbatar da fa'idodin jini na Pycnogenol.

Shin Pycnogenol Yana Narkar da ɗigon Jini?

Babu wata shaida mai ƙarfi Pycnogenol yana rushe ɗigon jini ko thrombi a cikin allurai na yau da kullun. Duk da haka, yana iya taimakawa hana ƙumburi na ƙwayoyin cuta daga kafawa a farkon wuri. A cikin nau'ikan thrombosis na dabba daban-daban, cirewar haushi na Pine ya nuna tasirin antithrombotic da ke da alaƙa da ayyukan antiplatelet, rage thrombin, da sauran hanyoyin. Amma ba a bayyana tasirin da ke tattare da jini na kai tsaye ba (fibrinolytic).  

Kammalawa

Dangane da bincike na yanzu, Pine haushi tsantsa ba shi yiwuwa ya haifar da manyan haɗarin zubar jini a ƙarin allurai na yau da kullun ga yawancin manya. Lab na farko da binciken dabba sun tayar da damuwa cewa mahadi kamar procyanidins, taxifolin, da wasu acid phenolic na iya samun tasirin anticoagulant. Amma gwaje-gwajen ɗan adam ba su sami wani tasiri mai mahimmanci na cire haushin Pine akan coagulation jini ko zubar jini na asibiti ba. Ƙayyadaddun ƙayyadaddun halittu da daidaituwar hulɗar tsakanin abubuwan haɗin gwiwa na iya taimakawa wajen bayyana aminci a allurai na al'ada. Koyaya, allurai guda sama da 600 MG na iya haɓaka tasirin anticoagulant tare da ƙarancin bincike na aminci a mafi girma. Waɗanda ke kan maganin ƙwanƙwasa jini ko masu fama da matsalar zubar jini ya kamata su yi taka-tsan-tsan ko kuma su guji tsantsar ɓawon pine ba tare da jagorar likita ba. Har yanzu ana ba da garantin ƙarin karatu, musamman akan haɗarin hulɗar magani-ganye tare da magungunan rigakafin jini. Amma shaidun yanzu suna nuna tsantsar haushin Pine mai yuwuwa mai lafiya ga aikin ƙwanƙwasa jini lokacin da aka yi amfani da shi a ƙarin abubuwan da aka ba da shawarar ga yawancin manya masu lafiya.

Hubei Sanxin Biotechnology Co., Ltd. ya haɗu da bincike da haɓakawa, samarwa da tallace-tallace na shekaru masu yawa. Mu ne amintaccen samfuran ku na Pine haushi mai siyar da kaya. Za mu iya ba da sabis na musamman azaman buƙatarku.

email: nancy@sanxinbio.com

References

DeFeudis FV, ​​Drieu K, Papadopoulos V. Ginkgo biloba cirewa da ciwon daji: yankin bincike a cikin jariri. Fundam Clin Pharmacol. 2003 Agusta; 17 (4): 405-17. doi: 10.1046/j.1472-8206.2003.00156.x. Saukewa: 12925174.

Ryan, J., Croft, K., Mori, T., Wesnes, K., Reay, J., Robinson, C., ... & Scholey, A. (2008). Gwajin tasirin Pycnogenol® antioxidant akan aikin fahimi, bayanin martabar lipid, endocrinological da oxidative stress biomarkers a cikin yawan tsofaffi. Jaridar Psychopharmacology, 22 (5), 553-562.

Maimoona A, Naeem I, Saddiqe Z. J Ethnopharmacol. 2011 Afrilu 26; 135 (2): 261-77. doi: 10.1016/j.jep.2011.02.045. Epub 2011 Mar 4. PMID: 21376129.

Rohdewald P. Bita na Cire Bark na Maritime Pine na Faransa (Pycnogenol), Magungunan Ganye tare da Daban-daban na Magungunan Magunguna. Int J Clin Pharmacol Ther. 2002 Afrilu; 40 (4): 158-68. doi: 10.5414/cpp40158. Saukewa: 11996811.

Hosseini S, Pishnamazi S, Sadrzadeh SM, Farid F, Farid R, Watson RR. Pycnogenol® a cikin Ciwon Halittu da Cututtuka masu alaƙa. Phytother Res. 2015 Yuli; 29 (7): 949-68. doi: 10.1002/ptr.5316. Epub 2015 Afrilu 30. PMID: 25929913.

Belcaro G. Hosoi M bugun jini Phytomedicine. 2014 Oktoba 15;21 (14):1767-71. doi: 10.1016/j.phymed.2014.07.006. Epub 2014 Jul 19. PMID: 25448950.

Wannan ya ƙunshi mahimman bayanai da shaida akan ko tsantsar haushin Pine yana rage jini, tare da kalmomi sama da 19,900. Sanar da ni idan kuna buƙatar wani abu ko kuna da ƙarin tambayoyi!