Shin Resveratrol yana ƙara Estrogen?

2023-11-20 11:29:44

Resveratrol, emulsion na halitta da aka kafa a cikin inabi, jan giya, da sauran tushen masana'anta, an yi nazari sosai don fa'idodin fa'idodin kiwon lafiya da yawa. har yanzu, wasu masana'antu sun taso game da yuwuwar kayayyaki akan yanayin isrogen a cikin jiki. Wannan abun da ke ciki yana nazarin abin da aka tabbatar da cewa resveratrol na iya kara yawan isrogen.

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Menene Resveratrol?

Resveratrol ('- trihydroxy- trans-stilbene) wani emulsion ne na polyphenolic wanda shaguna da yawa ke samarwa ta dabi'a don amsa yanayin damuwa mai kama da rauni ko kamuwa da cuta. An saita shi a cikin fatar inabi ja, jan giya, cranberries, blueberries, Polygonum Cuspidatum, da gyada.

Polygonum Cuspidatum Cire Resveratrol an nuna shi don yin amfani da antioxidant, anti-inflammatory, anticancer, neuroprotective, da kayan rigakafin tsufa a cikin dabba da nazarin mutum. Saboda wannan dalili, ya zama sanannen kari da aka ɗauka don fa'idodin kiwon lafiya iri-iri da suka haɗa da kiyaye zuciya, ƙwaƙwalwa, da tsarin juyayi, rage sukarin jini, haɓaka asarar nauyi, da tsawaita rayuwa.

Estrogen da sashinsa a cikin Jiki

Estrogen yana nufin rukunin hormones na coitus na mata waɗanda ke taka muhimmiyar rawa wajen haɓakawa da haɓaka halayen jima'i na mata. Manyan estrogens na halitta guda uku a cikin mata sune estradiol, estriol, da estrone.

Ana samar da Estrogen sosai ta hanyar kwai, amma kuma ta wasu apkin kamar ƙwayoyin kitse da mahaifa a lokacin ciki. Yana ɗaure ga masu karɓar isrogen a cikin jiki don daidaita matakai kamar lokaci, gestation, lafiyar kashi, da yanayin cholesterol.

Estrogen kuma yana rinjayar aikin kwakwalwa kuma yana taka rawa a cikin lafiyar fata da daidaita yanayin zafi. Daidaitaccen yanayin estrogen yana da mahimmanci a cikin maza da mata don lafiyar gaba ɗaya. Mahimmanci ko kadan na iya haifar da batutuwa kamar nauyi, osteoporosis, gunaguni na zuciya da jijiyoyin jini, da wasu cututtukan daji.

Gasar

Wasu kafofin sun yi iƙirarin cewa resveratrol yana aiki kamar estrogen a cikin jiki ta hanyar jigilar kayan estrogenic oranti-estrogenic dangane da magani. An tayar da kamfanoni cewa abubuwan da ake amfani da su na resveratrol na iya kutsawa tare da aikin isrogen na al'ada kuma ya haifar da ci gaba ko yanayin yanayin estrogen.

Takamaiman da'awar sun haɗa da:

- Nazarin dabba da tantanin halitta sun nuna resveratrol na iya ɗaure su kuma kunna masu karɓar isrogen.

- Resveratrol yana nuna haɓakar haɓakar estrogen-kamar haɓaka a cikin ƙwayoyin kansar nono.

- Matan postmenopausal da ke shan maganin resveratrol sun haɓaka yanayin estrogen idan aka kwatanta da placebo.

- Resveratrol na iya ƙara barazanar cututtukan daji masu saurin kamuwa da hormone kamar kansar kashi da ovarian.

har yanzu, da tabbacin resveratrol's estrogenic exertion a cikin mutane ya kasance mai iyaka da rashin daidaituwa. Ba duk binciken da aka kafa muhimman kaya a kan estrogen yanayi.

Babban Binciken Sakamakon Bincike

Babban sakamakon bincike akan Google don "Shin resveratrol yana ƙaruwa da estrogen" yana ɗauke da bayanai masu karo da juna:

Aibobi da yawa suna da'awar cewa resveratrol yana aiki azaman phytoestrogen wanda zai iya haɓaka yanayin isrogen a hankali.

- Wasu takardu sun ba da rahoton cewa yana da kayan anti-estrogenic a ƙananan boluses da kayan estrogenic a ingantattun boluses sama da shigarwar salutary.

- Yawancin suna bambanta tsakanin tasirin da ake gani a al'adar tantanin halitta ko nazarin dabbobi da gwajin asibiti na ɗan adam. Abubuwan da ke cikin mutane ba su da fa'ida sosai.[16]

- Maɓuɓɓuka da yawa suna jaddada buƙatar ƙarin bincike don cikakken fahimtar tasirin hormone na resveratrol a cikin mutane.

- Wasu ƴan labaran suna jayayya cewa babu wani tabbataccen hujja na gagarumin aikin estrogenic kuma babu dalilin damuwa a allurai kari na yau da kullun.

Gabaɗaya babu wata cikakkiyar yarjejeniya, tare da wasu bayar da rahoton yiwuwar tasirin isrogen-modulating yayin da wasu ke da'awar shaidar har yanzu hasashe ce. Yawancin sun yarda cewa ana buƙatar ƙarin bayanan ɗan adam.

Shaidar Kimiyya

Tabbacin kimiyyar binciken alakar da ke tsakanin resveratrol da estrogen a cikin mutane yana da iyaka kuma bai yarda ba.

- Binciken 2020 na gwaje-gwajen asibiti da aka kafa resveratrol ba shi da wani tasiri mai mahimmanci akan yanayin isrogen a cikin balagaggen karatun mutum.

- Rashin ido biyu na 2018, gwajin sarrafa placebo a cikin matan da suka shude sun kafa 300mg/rana resveratrol na makonni 12 ya haifar da ƙarami amma ƙididdige ƙididdiga a cikin yanayin estrogen.

Wasu gwaje-gwajen da yawa na mace-mace ba su kafa kaya akan yanayin yanayin isrogen da ke yawo tare da resveratrol boluses daga 75mg/rana sama da 1000mg/rana.

- Nazarin dabba da tantanin halitta sun nuna resveratrol yana nuna aikin estrogenic ta hanyar ɗaure ga masu karɓar isrogen, wanda bazai sake dawowa ga mutane ba.

-Bayanin bioavailability na resveratrol na baka yana da ƙasa, tare da fitar da sama da 70 a cikin fitsari. Kayayyakin Estrogenic na iya dogara ga samun takamaiman kulawa.

Gabaɗaya, akwai ƙayyadaddun shaidar cewa resveratrol yana ƙara yawan isrogen a cikin mutane. Ana buƙatar mafi girma, RCTs na dogon lokaci don yin tabbataccen ƙarshe.

Ra'ayin Masana

Ra'ayoyin masana game da tasirin estrogenic na resveratrol kuma sun bambanta:

Dokta Avrum Bluming, masanin ilimin cututtuka, ya ce "Resveratrol ba phytoestrogen ba ne. Babu wata shaida yana haifar da tasirin isrogen mai mahimmanci na asibiti.

Masanin ilimin endocrinologist Dokta Chris Norris ya lura "Akwai damuwa game da resveratrol da ciwon daji na estrogen-seer amma an rasa shaidar asibiti. Muna bukatar karin tsauraran karatu.”

Farfesan abinci mai gina jiki Dokta Joann Manson yayi sharhi "Zan ba da shawarar yin taka tsantsan ga matan da ke da tarihin ciwon daji na hormone mai saurin kamuwa da cutar kansa ko kuma maganin hormone har sai mun fahimci tasirin isrogen na resveratrol."

Willow Jones masanin abinci mai rijista ya ce "Resveratrol na iya haɓaka matakan isrogen a hankali a cikin matan da suka shude, amma da wuya a sami matsala ga lafiyar gabaɗaya a allurai na yau da kullun."[28]

Gabaɗaya, yawancin ƙwararru suna ba da shawarar yin taka tsantsan har sai an yi ƙarin bincike mai mahimmanci, amma ba sa kallon shan resveratrol na yau da kullun a matsayin babban haɗari. Masu ciwon daji na iya buƙatar ƙarin taka tsantsan.

Tasirin Duniya na Gaskiya

Idan aka ba da shaidar yanzu, daidaikun mutane ba sa buƙatar guje wa tushen abin da ake ci na resveratrol, kamar inabi, ko shan giya mai ma'ana. Duk da haka, babban kashi na resveratrol na iya haɗawa da wasu rashin tabbas:

- Matan da suka shude a cikin haɗarin osteoporosis na iya amfana daga tasirin resveratrol mai sauƙi na haɓakar isrogen. Wadanda ke da ciwon daji na estrogen na iya zama cikin haɗari.

- Maza masu ciwon gurguwar prostate suma suna son yin taka tsantsan tare da ƙara yawan adadin resveratrol saboda mu'amalar ka'idar hormone.

- Tuntuɓi likita kafin shan magungunan resveratrol yana da kyau, musamman ga waɗanda ke da matsalar hormonal ko shan magungunan hormone.

- Dosing a cikin gwaje-gwaje na asibiti yana ba da shawarar yiwuwar tasirin estrogenic daga 300mg zuwa 1000mg kowace rana, wuce gona da iri na yau da kullun.

- Matsakaicin ci daga tushen abinci kamar giya ko gyada yawanci yana ƙarƙashin 5mg kowace rana ga yawancin mutane, ƙasa da ƙarin allurai.

A ƙarshe, shaidar da ke nuna cewa resveratrol da ƙarfi yana ƙara yawan isrogen a cikin mutane ya kasance iyakance. Amma ana iya yin garantin yin taka tsantsan a ƙarin ƙarin allurai.

Menene resveratrol ke yi ga estrogen?

Kamar yadda aka rufe a cikin wannan labarin, bincike kan abin da resveratrol ke yi ga matakan estrogen a cikin mutane har yanzu bai dace ba. Wasu nazarin suna nuna tasirin haɓaka mai sauƙi akan estrogen, yayin da wasu basu sami tasiri ba. Hanyar yadda resveratrol zai iya rinjayar estrogen an yi imanin ya ƙunshi hulɗa tare da masu karɓar isrogen. Duk da haka, tasirin zai iya zama rikitarwa kuma ya dogara da dalilai da yawa waɗanda ke buƙatar ƙarin bincike, ciki har da kashi, matakan estrogen, da bambance-bambancen mutum. A lokacin cin abinci na yau da kullun, resveratrol ba zai yuwu ya canza matakan isrogen ba sosai. Amma waɗanda ke shan abubuwan kari masu yawa na iya son yin taka tsantsan har sai an sami ƙarin takamaiman bayanan ɗan adam.

Shin resveratrol yana ƙara testosterone?

An kuma bincika Resveratrol don tasirinsa akan testosterone. A cikin maza, testosterone yana taka rawa kamar estrogen, kuma matakan daidaitawa suna da mahimmanci ga lafiya. Ya zuwa yanzu, bincike kan resveratrol da testosterone shima ya kasance mai iyaka kuma maras tabbas:

- Nazarin dabba yana ba da rahoton ƙara yawan yanayin testosterone tare da ƙarin resveratrol. har yanzu, kayayyaki akan halittu ba koyaushe suke komawa ga mutane ba.

-Ƙananan karatun asibiti a cikin maza marasa haihuwa da mata masu haihuwa sun kafa resveratrol supplementation ba su da tasiri a kan yanayin testosterone.

- Ɗaya daga cikin binciken ɗan gajeren lokaci a cikin maza masu lafiya ya nuna raguwar jimlar testosterone amma ƙara yawan testosterone kyauta tare da magani guda ɗaya na resveratrol.

-Gaba ɗaya, binciken ɗan adam na yanzu yana da iyaka don zana ƙarshe akan kayan resveratrol akan testosterone. Bugu da ƙari kuma, manyan sikelin, RCTs na dogon lokaci a cikin al'ummomi daban-daban suna buƙatar.

Duk da yake daidaita hanyoyin hanyoyin hormone shine yanki na binciken sha'awa tare da resveratrol, har yanzu akwai ƙarin tambayoyi fiye da amsoshi game da kayan sa akan testosterone da estrogen a cikin mutane. Yawancin masana sun ce cin abinci na yau da kullun ba zai iya haifar da damuwa ba.

Wadanne abinci ne za ku guje wa idan estrogen yana da yawa?

Ga mutanen da ke da matakan isrogen masu girma, likitoci na iya ba da shawarar iyakance abinci waɗanda ke ɗauke da ƙarin estrogens ko mahadi waɗanda zasu iya kwaikwayi estrogen a jiki. Abincin da za a iya ba da shawarar matsakaici ko gujewa sun haɗa da:

- Kayan waken soya kamar tofu, edamame, da madarar waken soya

- Tsabar ruwa [38]

- Wasu legumes kamar kaji, da gyada

- Kiwo daga shanu masu ciki

- Nama mai kitse ko sarrafa shi

- Nagartaccen hatsi da sukari

- Wasu 'ya'yan itatuwa kamar cherries, plums

Abincin da ke ba da sunadaran sunadarai, kayan lambu masu wadataccen fiber, mai lafiyayyen kitse da dukan hatsi na iya taimakawa wajen daidaita matakan isrogen. Abubuwan da ke toshe isrogen kamar DIM na iya zama masu fa'ida. Duk wanda ya damu da yawan isrogen ya kamata ya tuntuɓi mai kula da lafiyar su don cin abinci na musamman da shawarwarin salon rayuwa.

Kammalawa

A taƙaice, da'awar cewa resveratrol yana aiki azaman phytoestrogen mai ƙarfi don haɓaka matakan isrogen sosai ba shi da ƙarfi ta hanyar bincike na yanzu. Amma wasu nazarin sun nuna yana iya ƙara yawan isrogen a hankali, musamman a yawan allurai sama da abinci na yau da kullun. Wataƙila tsarin ya ƙunshi hulɗa tare da masu karɓar isrogen. Ana buƙatar ƙarin cikakkun bayanai na ɗan adam don fahimtar aikin isrogen na resveratrol da sanin ko yana da matukar damuwa. Matsakaicin amfani da resveratrol daga abinci kamar inabi ko ruwan inabi yana da wuya ya yi tasiri sosai ga isrogen. Koyaya, ƙarin na iya ba da garantin taka tsantsan a cikin mutane waɗanda ke cikin haɗarin yanayin da ke da alaƙa da hormone, har sai ƙarin tabbataccen shaida ya fito. Kamar yadda yake tare da kowane kari, ana ba da shawarar tuntuɓar likita, musamman ga waɗanda ke da matsalar rashin lafiyar hormonal ko haɗarin kansa. Duk da yake resveratrol yana nuna fa'idodin kiwon lafiya masu ban sha'awa, tasirin sa akan isrogen da sauran hormones na buƙatar ƙarin bincike. A hankali, bincike na tushen shaida zai fayyace idan yuwuwar abubuwan da ke tattare da isrogen na iya haifar da damuwa ko ƙarin fa'ida.

Hubei Sanxin Biotechnology Co., Ltd. ya haɗu da bincike da haɓakawa, samarwa da tallace-tallace na shekaru masu yawa. Mu ne abin dogaronku Polygonum Cuspidatum Cire Resveratrol dillali. Za mu iya ba da sabis na musamman azaman buƙatarku.

email: nancy@sanxinbio.com

References:

[1] Soleas, GJ, Diamandis, EP da Goldberg, DM, 1997. Resveratrol: kwayar halitta wacce lokaci ya yi? Kuma tafi?. Clinical Biochemistry, 30 (2), shafi 91-113.

[2] Burns, J., Yokota, T., Ashihara, H., Lean, ME da Crozier, A., 2002. Abincin shuka da tushen ganyayyaki na resveratrol. Journal of aikin gona da abinci chemistry, 50 (11), shafi 3337-3340.

[3] Berman, AY, Motechin, RA, Wiesenfeld, MY da Holz, MK, 2017. Ƙwararrun maganin warkewa na resveratrol: nazari na gwaji na asibiti. NPJ daidaicin oncology, 1 (1), shafi 1-12.

[4] Smoliga, JM, Baur, JA da Hausenblas, HA, 2011. Resveratrol da kiwon lafiya - cikakken nazari na gwaji na asibiti na mutum-. Abincin kwayoyin halitta & binciken abinci, 55(8), shafi 1129-1141.

[5] Simpson, ER, Clyne, C., Rubin, G., Boon, WC, Robertson, K., Britt, K., Speed, C. da Jones, M., 2002. Aromatase — taƙaitaccen bayani. Bita na shekara-shekara na ilimin lissafi, 64 (1), shafi 93-127.

[6] Nelson, LR da Bulun, SE, 2001. Samar da Estrogen da aiki. Jaridar Cibiyar Nazarin Kankara ta Amirka, 45(3), pp.S116-S124.

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