Wani nau'in magani ne camptothecin?

2024-01-17 11:02:21

Camptothecin, alkaloid da ke faruwa a zahiri, na cikin fitattun nau'ikan masu hana topoisomerase, suna taka muhimmiyar rawa a cikin ilimin cutar kansa. Camptotheca acuminata cire ya kawo sauyi na maganin ciwon daji ta hanyar yin niyya na musamman na enzymes da ke da hannu wajen yin kwafi da gyara DNA, ta yadda hakan ke hana ci gaban kwayoyin cutar kansa. Hanya na musamman na Camptothecin da abubuwan da suka samo asali sun zama kayan aiki don haɓaka ingantattun dabarun warkewa daga cututtuka daban-daban.

Topoisomerases da Dokokin DNA:

Topoisomerases sune mahimman enzymes waɗanda ke daidaita tsarin topological na DNA yayin mahimman hanyoyin salon salula kamar kwafi, kwafi, da gyarawa. Wadannan enzymes suna tabbatar da daidaitaccen kwancewa da iska na helix na DNA sau biyu, suna hana tarawa na torsional. A cikin sel ciwon daji, rarrabuwar da ba a sarrafa da sauri tana buƙatar aiwatar da ayyukan DNA masu aiki, yana sanya topoisomerases kyakkyawan manufa don shiga tsakani.

Hanyar Aiki na Camptothecin:

Camptothecin yana aiwatar da tasirin anticancer ta musamman niyya topoisomerase I, maɓalli mai mahimmancin enzyme da ke cikin kwafin DNA. A yayin aiwatar da maimaitawa, topoisomerase I ne ke da alhakin kawar da damuwa ta ɓacin rai ta hanyar ƙirƙirar ɓoyayyiyar igiya guda ɗaya a cikin DNA. Camptothecin yana rushe wannan tsari ta hanyar ɗaure ga hadaddun enzyme-DNA, yana hana addini na DNA strand. Samuwar rukunonin da ba za a iya jurewa ba yana haifar da lalacewar DNA, a ƙarshe yana haifar da apoptosis a cikin ƙwayoyin kansa.

Abubuwan Samfuran Camptothecin da Muhimmancin Asibiti:

Duk da yake camptotheca acuminata cirewa kanta yana da iyakokin da ke da alaƙa da narkewa da kwanciyar hankali, abubuwan da suka samo asali sun magance waɗannan ƙalubalen, suna mai da su mahimmanci a asibiti. Irinotecan da topotecan sune manyan abubuwan asali guda biyu waɗanda suka sami amincewa don maganin cututtukan daji daban-daban. Ana amfani da Irinotecan a cikin ciwon daji na colorectal, yayin da ake amfani da topotecan a cikin ciwon daji na ovarian da huhu. Waɗannan abubuwan haɓaka suna nuna ingantattun kaddarorin harhada magunguna, suna haɓaka ingancinsu da rage yawan guba.

Kalubale na asibiti da Bincike mai gudana:

Duk da nasarar abubuwan da aka samo na camptothecin, ƙalubalen sun ci gaba, gami da haɓaka juriya na miyagun ƙwayoyi da sakamako masu illa. Masu bincike suna binciko sabbin dabaru don shawo kan waɗannan matsalolin. Nanoparticles, hanyoyin kwantar da hankali, da tsarin bayarwa da aka yi niyya ana kan bincike don inganta jigon jiyya na abubuwan da aka samo na camptothecin da haɓaka amfanin aikin su na asibiti.

Camptotheca acuminata.jpg

Wani irin alkaloid ne camptothecin?

Ajin alkaloid quinoline ya haɗa da camptothecin, alkaloid mai maganin ciwon daji mai ƙarfi. Da farko da aka samu a tsakiyar 1960s, tun daga lokacin an gane camptothecin a matsayin wani abu mai mahimmanci na halitta tare da tasirin cytotoxic mai ban mamaki akan ƙwayoyin girma na m. Halayen camptothecin a matsayin quinoline alkaloid yana ba da ƙarin haske game da abubuwan da ke cikinsa na ban mamaki da kuma sanya shi a cikin tarin alkaloids masu bioactive da aka gano a cikin nau'ikan tsirrai daban-daban.

Alkaloids na Quinoline:

Alkaloids na Quinoline sun ƙunshi haɗuwa daban-daban na gaurayawan yau da kullun da aka kwatanta ta kashin baya na farko wanda ke ɗauke da tsarin zoben quinoline. Wannan nau'in alkaloids gabaɗaya ana yaɗuwa a cikin daular shuka kuma an zana shi cikin la'akari sosai saboda darussan sa na harhada magunguna, gami da maganin zazzabin cizon sauro, kwantar da hankali, da kuma maganin ciwon daji. Camptothecin, tare da tsarinsa na quinoline marar kuskure, yana kwatanta ma'anar magunguna na quinoline alkaloids game da maganin cututtuka.

Tsarin Camptothecin:

An bayyana tsarin sinadarai na Camptothecin ta hanyar tsarin zobe na pentacyclic, tare da quinoline tsakiya a matsayin tushensa na tsakiya. Filin yana da zoben lactone, zobe mai membobi biyar na iskar oxygen, wanda ke taka muhimmiyar rawa a cikin ayyukansa na halitta. Wannan zobe na lactone yana da saukin kamuwa da hydrolysis, yana canza camptothecin zuwa nau'in carboxylate mara aiki. Ma'auni tsakanin nau'ikan lactone da carboxylate yana da mahimmanci don ingantaccen fili, kuma masu bincike sun bincika dabarun daidaita nau'in lactone mai aiki don dalilai na warkewa.

Tushen Halitta da Amfanin Gargajiya:

Camptothecin foda An samo asali ne daga bishiyar Camptotheca acuminata na kasar Sin, ko da yake an gano shi a cikin wasu nau'in tsire-tsire, ciki har da Nothapodytes nimoniana da nau'in Ophiorrhiza. A cikin magungunan gargajiya na kasar Sin, an yi amfani da abubuwan da aka samu daga Camptotheca acuminata, da aka fi sani da "Xi Shu," don samun damar maganin su. Gano camptothecin a cikin waɗannan tsire-tsire ya haifar da sha'awar amfani da ethnobotanical da kuma binciken sauran alkaloids tare da yuwuwar warkewa.

Menene tsarin aikin camptothecin?

A cikin tushen tsarin aikin camptothecin ya ta'allaka ne da ƙarfinsa na hana topoisomerase I, wani muhimmin enzyme mai shiga cikin metabolism na DNA. Topoisomerases suna taka muhimmiyar rawa wajen daidaita yanayin yanayin DNA ta hanyar haifar da hutu na wucin gadi a cikin sassan DNA, yana ba da damar kwancewa da kwance damarar helix biyu yayin matakai kamar kwafi da kwafi.

Camptothecin foda ayyuka ta hanyar ɗaure zuwa topoisomerase I-DNA hadaddun a lokacin da catalytic sake zagayowar. Yana hulɗa ta musamman tare da wurin daurin DNA na enzyme kuma yana samar da barga mai rikitarwa. Maimakon hana aikin enzyme, camptothecin yana hana sake kunnawa na DNA strand breaks wanda ke faruwa a yayin aiki na yau da kullum na topoisomerase I. Wannan yana haifar da samuwar tarkace da ba za a iya jurewa ba, wanda ke haifar da tarin lalacewar DNA a cikin kwayoyin cutar kansa.

Tasirin camptothecin yana da alaƙa sosai da zagayowar tantanin halitta, musamman lokacin S, inda kwafin DNA ke faruwa. A wannan lokaci, sel sun fi dacewa da tasirin topoisomerase inhibitors kamar camptothecin. Ta hanyar tarwatsa kwafin DNA a cikin rarrabuwar ƙwayoyin kansa cikin hanzari, camptothecin yana haifar da tasirin cytotoxic a zaɓi a cikin yawan adadin tantanin halitta. Hana topoisomerase I ta hanyar camptothecin yana haifar da tarawar karyawar DNA guda ɗaya. Ci karo na gaba na cokali mai yatsu tare da waɗannan hutun yana haifar da samuwar ɓangarorin DNA guda biyu, nau'in lalacewar DNA na cytotoxic sosai. Dagewar da ba a gyare-gyaren tsage-tsalle guda biyu yana haifar da hanyoyin apoptotic, yana ba da gudummawa ga kawar da ƙwayoyin cutar kansa.

A ƙarshe, camptothecin yana riƙe da keɓaɓɓen wuri a matsayin mai hana topoisomerase, yana ba da gudummawa sosai ga arsenal na magungunan cutar kansa. Zaɓin zaɓin da ya yi na tsarin kwafin DNA a cikin ƙwayoyin kansa ya buɗe hanya don haɓaka abubuwan da suka dace na asibiti. Nasarar irinotecan da topotecan yana nuna mahimmancin camptothecin a cikin maganin ciwon daji na zamani. Binciken da ake ci gaba da yi na nufin magance kalubalen da ke da alaka da juriya da illolin kwayoyi, da tabbatar da cewa wannan rukunin magungunan na ci gaba da taka muhimmiyar rawa wajen yaki da cutar kansa.

Hubei Sanxin Biotechnology Co., Ltd. ya haɗu da bincike da haɓakawa, samarwa da tallace-tallace na shekaru masu yawa. Mu ne abin dogaronku camptotheca acuminata cirewa dillali. Za mu iya ba da sabis na musamman azaman buƙatarku.

email: nancy@sanxinbio.com


References:

  1. Pommier, Y. (2006). Topoisomerase I inhibitors: camptothecins da kuma bayan. Nature Reviews Cancer, 6(10), 789-802.

  2. Hsiang, YH, Liu, LF, & bango, ME (1989). DNA topoisomerase I-mediated DNA cleavage da cytotoxicity na camptothecin analogs. Binciken Ciwon daji, 49 (18), 5077-5082.

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