Menene Camptotheca acuminata ake amfani dashi?

2024-01-17 10:44:29

Camptotheca acuminata, wanda aka fi sani da Bishiyar Farin Ciki ko Bishiyar Ciwon daji, itace itace mai tsiro a cikin kasar Sin da sassa daban-daban na Gabashin Asiya. Wannan bishiyar mai mahimmanci ta tattara la'akari da ainihin mahimmancinta kuma, mafi mahimmanci, don kasancewar gauraye masu ƙarfi a cikin haushi da ganye. Don yuwuwar su a matsayin magunguna, musamman a fagen binciken cutar kansa, abubuwan farko na camptotheca acuminata cirewa sun kasance batun bincike mai zurfi.

Muhimmancin Tarihi:

Bishiyar Farin Ciki tana da tarihin amfani da al'ada a cikin magungunan kasar Sin. An daɗe da yin amfani da gundumomi daban-daban na bishiyar, da suka haɗa da bawonta da ganyayenta, don magance ɗimbin matsalolin kiwon lafiya. Ala kulli hal, sai bayan tsakiyar karni na ashirin ne masana kimiyya suka fara bankado abubuwan ban mamaki da bishiyar ke da ita wajen magance cutar daji.

Mabuɗin Haɗin Halitta:

Babban mahadi na bioactive na farko a cikin Camptotheca acuminata sune camptothecins, aji na alkaloids tare da sanannen aikin antitumor. Abubuwan da aka fi nazari guda biyu na camptothecin sune topotecan da irinotecan, dukansu an ƙirƙira su zuwa magungunan rigakafin ciwon daji da aka yi amfani da su a asibiti.

Abubuwan Anticancer:

Camptothecins aiwatar da tasirin maganin cutar kansa ta hanyar hana ayyukan enzyme topoisomerase I, wani muhimmin enzyme da ke cikin kwafi da gyara DNA. Ta hanyar tsoma baki tare da wannan tsari, camptothecins yana hana ƙwayoyin ciwon daji daga rarrabuwa da haɓaka, yana mai da su wani abu mai mahimmanci a cikin maganin cututtuka daban-daban.

Aikace-aikace na asibiti:

Topotecan da irinotecan, waɗanda aka samo daga Camptotheca acuminata, sun sami aikace-aikace a cikin maganin ovarian, colorectal, da ƙananan ƙwayoyin huhu. Ana amfani da waɗannan magungunan ko dai a matsayin jiyya na tsaye ko a hade tare da wasu magungunan chemotherapeutic, suna nuna nau'i-nau'i na Camptotheca acuminata da aka samu a cikin maganin ciwon daji.

Camptotheca acuminata cire ya tsaya ne a matsayin shaida kan tsattsauran dangantaka tsakanin magungunan gargajiya, binciken kimiyya, da bunƙasa magunguna na zamani. Amfani da bishiyar farin ciki ta tarihi a cikin likitancin kasar Sin, tare da gano ta a matsayin tushen madogarar magungunan cutar kansa, yana misalta yuwuwar yanayi don samar da hanyoyin magance kalubalen likitanci masu sarkakiya.

Camptotheca acuminata.jpg

Wane irin magani ne camptothecin?

Camptothecin, wani fili na halitta tare da kyawawan kaddarorin anticancer, na cikin aji na masu hana topoisomerase. An gano shi a farkon shekarun 1960, camptothecin da abubuwan da suka samo asali sun zama mahimman abubuwan da ke tattare da cutar kansar cutar sankara saboda ikon su na rushe hanyoyin kwafin DNA, musamman ta hanyar hana topoisomerase I. Fahimtar hanyoyin musamman na camptothecin yana ba da haske game da aikace-aikacen warkewa da ci gaba da bincike don haɓakar magungunan rigakafin cutar daji mafi inganci.

An wakilta Camptothecin alkaloid cytotoxic kuma an keɓe shi da gaske daga haushi da mai tushe na bishiyar Sinawa Camptotheca acuminata. An yi amfani da wannan shuka a al'ada a cikin magungunan kasar Sin, kuma bayyanar camptothecin yana nuna muhimmiyar nasara a cikin neman sababbin magungunan cutar kansa daga tushen halitta.

Babban makasudin camptothecin shine topoisomerase I, wani enzyme mai mahimmanci don kwafi da gyara DNA. Topoisomerases suna taka muhimmiyar rawa wajen kiyaye tsari da mutuncin DNA ta hanyar sarrafa iska da kwancen helix na DNA sau biyu. Camptothecin yana ɗaure zuwa topoisomerase I-DNA hadaddun, yana hana sake haɗawar karyawar DNA da aka haifar yayin maimaitawa. Wannan yana haifar da samuwar hadaddun da ba za a iya jurewa ba, a ƙarshe yana hana kwafin DNA da haifar da lalacewar DNA a cikin ƙwayoyin kansa.

Duk da nasarar da camptothecin foda abubuwan da suka samo asali, ƙalubalen sun ci gaba, gami da juriya na ƙwayoyi da illolinsu. Masu bincike suna ci gaba da bincika sabbin dabaru don inganta ingantaccen magani na camptothecin, irin su nanoparticle formulations da hanyoyin haɗin gwiwa. Fahimtar hanyoyin ƙwayoyin ƙwayoyin cuta na juriya da haɓaka tsarin isar da niyya wurare ne masu aiki na bincike.

Camptothecin, a matsayin mai hana topoisomerase, yana wakiltar gagarumin ci gaba a fagen ciwon daji na chemotherapy. Zaɓin zaɓin da ya yi na tsarin kwafi na DNA a cikin ƙwayoyin kansa ya sanya ya zama kayan aiki mai mahimmanci a cikin maganin cututtuka daban-daban. Haɓaka abubuwan haɓakawa tare da ingantattun kaddarorin suna nuna ƙoƙarin ci gaba don shawo kan ƙalubalen da ke tattare da mahallin mahaifa. Yayin da bincike ke ci gaba, zurfin fahimtar hanyoyin camptothecin da sabbin hanyoyin inganta hanyoyin warkewa na iya haifar da ci gaba a cikin maganin cutar kansa.

Ta yaya camptothecin ke aiki?

Camptothecin foda tasirin anticancer ta hanyar yin niyya da hana ayyukan topoisomerase I, wani muhimmin enzyme wanda ke cikin kwafin DNA da kwafi. A al'ada, topoisomerase I yana sauƙaƙa supercoiling na DNA ta hanyar gabatar da hutun madauri ɗaya na wucin gadi da ƙyale igiyoyin DNA su buɗe. Koyaya, camptothecin ba zai sake dawowa ba yana ɗaure zuwa hadadden cleavage da topoisomerase I da DNA suka yi. Wannan yana hana sake haɗa igiyoyin DNA, wanda ke haifar da tarawar DNA guda biyu karya. Lalacewar tsarin DNA na gaba yana rushe mahimman hanyoyin salula, yana haifar da apoptosis, kuma a ƙarshe yana hana ci gaban ƙari.

Camptotheca acuminata azaman maganin ciwon daji

Bayyanar camptothecin da sashin aikinsa ya buɗe sabbin hanyoyi don maganin ciwon daji. Kwararru nan da nan suka fahimci iyawar sa na gaskiya kuma suka fara ƙirƙirar masu ƙarƙashin na camptothecin don haɓaka isasshiyar taimakonsa da rage illolin. Wasu ƴan analogues na camptothecin, alal misali, irinotecan da topotecan, ƙwararrun gudanarwa na gudanarwa sun amince da su kuma ana amfani da su gabaɗaya wajen maganin ciwace-ciwace daban-daban. Irinotecan ana amfani dashi akai-akai a cikin maganin cututtukan launin fata kuma ya nuna sakamako mai ban sha'awa a cikin cututtuka daban-daban, gami da huhu da ci gaban pancreatic. Ana ba da umarnin ta cikin hanji kuma an canza shi zuwa SN-38 mai ƙarfi metabolite. SN-38 yana hana topoisomerase I ta hanya kamar camptothecin kuma yana damun kwafin DNA da gyarawa a cikin ƙwayoyin girma mara kyau. Topotecan, sa'an nan kuma, ana amfani da shi da gaske a cikin maganin ovarian da ƙananan ƙwayar salula a cikin huhu. Hakanan yana danne topoisomerase I, kuma ingantaccen amfani da shi a cikin waɗannan cututtukan ya haifar da ƙarin bincike don yuwuwar aikace-aikace a cikin wasu haɓaka mai ƙarfi. Duk da irinotecan da topotecan, wasu 'yan wasu analogs na camptothecin a halin yanzu suna ta hanyar preclinical da na asibiti. Waɗannan gwaje-gwajen suna tsammanin haɓaka iyakokin nau'ikan cututtukan waɗanda za a iya bi da su da gaske tare da ƙayyadaddun magungunan camptothecin da haɓaka ma'anar magunguna na zamani don haɓaka isar da isar da kuma rage tasirin da ke faruwa.

Tuntube Mu

Hubei Sanxin Biotechnology Co., Ltd. ya haɗu da bincike da haɓakawa, samarwa da tallace-tallace na shekaru masu yawa. Mu ne abin dogaronku camptotheca acuminata cirewa dillali. Za mu iya ba da sabis na musamman azaman buƙatarku.

email: nancy@sanxinbio.com

References:

  1. Wall, ME, Wani, MC, Cook, CE, Palmer, KH, McPhail, AT, & Sim, GA (1966). Shuka magungunan antitumor. I. Warewa da tsarin camptothecin, labari na alkaloidal cutar sankarar bargo da ƙari mai hanawa daga Camptotheca acuminata1, 2. Journal of the American Chemical Society, 88 (16), 3888-3890.

  2. Hsiang, YH, Hertzberg, R., & Hecht, S. (1985). Camptothecin yana haifar da karyawar DNA mai alaƙa da furotin ta hanyar DNA na mammalian topoisomerase I. Jarida na ilmin sunadarai, 260(27), 14873-14878.

Ilimin Masana'antu masu alaƙa