Menene Dihydromyricetin?

2023-11-13 12:01:53

Dihydromyricetin (DHM) wani fili ne na flavonoid na halitta wanda kwanan nan ya sami kulawa don tasiri mai karfi akan lafiya da metabolism. Wannan labarin zai bincika menene DHM, tushen sa, kaddarorinsa, aikace-aikace, da yanayin bincike na yanzu.

二氢杨梅素.jpg

Menene Dihydromyricetin?

Dihydromyricetin, wanda kuma aka sani da ampelopsin, flavanonol, wani nau'in antioxidant na flavonoid da ake samu a cikin tsire-tsire daban-daban. A kimiyyance, an samo shi daga flavonoid myricetin ta hanyar hydrogenation na haɗin 2,3-biyu.

Dihydromyricetin foda yana da dogon tarihin amfani da maganin gargajiya na kasar Sin. Kwanan nan ya zama batun binciken kimiyya don amfanin lafiyarsa.

Takaitaccen Bayani da Amfanin Gargajiya

An yi amfani da mai tushe da ganyen bishiyar Hovenia dulcis, wanda kuma aka sani da itacen inabi na Japan ko itacen zabibi na gabas, a cikin shirye-shiryen magungunan gargajiya na kasar Sin tsawon ƙarni. An fara keɓe DHM daga H. dulcis a cikin 1970s.

A al'adance, ana amfani da DHM don magance gubar barasa da yanayin hanta. Ana ci gaba da amfani da shi a cikin Magungunan gargajiya na kasar Sin a yau.

Muhimmancin Fahimtar DHM

Keɓaɓɓen sinadarai da ilimin harhada magunguna na DHM suna nuni ga nau'ikan hanyoyin warkewa da haɓakar lafiya waɗanda ke ba da damar ƙarin bincike. Fahimtar tsarin sinadarai, ayyukan nazarin halittu, da tushe na iya taimakawa bincike da aikace-aikace.

Haɗin Sinadari da Tushen Halitta

Tsarin kwayoyin halitta

Tsarin kwayoyin halitta na DHM shine C15H14O7. Tsarin sinadaransa ya ƙunshi zoben benzene guda biyu da aka haɗa ta gadar carbon-3, tare da ƙungiyoyin hydroxyl da yawa. DHM yayi kama da sauran mahadi na flavonoid. [1]

Tushen Halitta

Ana samun DHM a wurare daban-daban na shuka, gami da:

Hovenia dulcis (bishiyar zabibi na Japan) - mai tushe, ganye, 'ya'yan itace

Ampelopsis grossedentata ( shayin inabi)

- Acacia rikice (KImage: : tunani: uzzing wattle)

- Metasequoia glyptostroboides (janyewar alfijir)

An ciro DHM na kasuwanci da farko daga H. dulcis saboda babban abun ciki. [2]

Ciro da Tsarkakewa

Dihydromyricetin Bulk Foda ana iya fitar da su daga tushen shuka ta amfani da abubuwan kaushi kamar gaurayawan barasa/ruwa. Tsarkake sau da yawa ya ƙunshi chromatography shafi da kuma shirye-shiryen HPLC. Tsaftar DHM da yawan amfanin ƙasa na iya bambanta sosai dangane da fasaha. [3]

Pharmacological Properties

Bincike ya nuna DHM yana da kewayon fa'idodin magunguna masu fa'ida:

M Antioxidant da Anti-mai kumburi Effects

DHM yana nuna ƙaƙƙarfan ayyukan ɓarna mai tsattsauran ra'ayi a cikin vitro. Nazarin dabba ya nuna yana rage alamomin damuwa da kumburi a cikin kyallen takarda. [4]

Yana Tasirin Barasa Metabolism

DHM yana hanzarta kawar da barasa ta hanyar haɓaka aikin hanta barasa dehydrogenase da metabolism acetaldehyde. An yi imanin wannan yana ba da gudummawa ga tasirin jin daɗin sa. [5]

Aikace-aikace masu yuwuwa a cikin Lafiyar Hanta

DHM na iya taimakawa wajen magancewa da hana lalacewar hanta ta hanyar kare ƙwayoyin hanta, rage yawan kitse, haɓaka haɓakawa, da kuma haifar da tasirin antioxidant. [6]

Ci gaba da bincike na ci gaba da gano hanyoyin da ke bayan ayyukan nazarin halittu na DHM.

Bincike da Bincike na Kimiyya

Mahimmin bincike yana nuna alƙawarin Dihydromyricetin foda:

Tasirin Barasa Metabolism da Guba

Nazarin ɗan adam da na dabba da yawa sun nuna ikon DHM na saurin kawar da barasa daga jini da rage tsananin rashin ƙarfi. Hakanan yana kare hanta daga raunin da ya haifar da barasa. [7]

Amfanin Lafiyar Hanta

Nazarin ya nuna DHM yana da alƙawarin inganta cututtukan hanta mai ƙiba da hana hanta fibrosis. Yana nuna ayyukan hepatoprotective a cikin nau'ikan dabbobi na hanta mai guba da cuta. [8]

Sauran Abubuwan Amfani masu Yiyuwa

Binciken farko yana nuna neuroprotective, antimicrobial, rigakafi-stimulating, da anticancer Properties na DHM. Ana buƙatar ƙarin karatu don tabbatar da tasiri da aikace-aikace. [9]

Gabaɗaya, DHM yana nuna yuwuwar hanyoyin warkewa daban-daban waɗanda ke ba da garantin ƙarin bincike.

Amfanin Masana'antu da Kasuwanci

DHM yana girma cikin shahara a matsayin sinadari da kari:

abin da ake ci Kari

DHM yawanci ana samun su a cikin abubuwan kari da aka yi kasuwa don jin daɗin hanta, hanta detox/lafiya, ko azaman antioxidant. Shahararrun nau'ikan sun haɗa da capsules, foda, da allunan. [10]

Abincin Giya

Kamfanonin abin sha sun haɗa DHM cikin samfuran da ke magance metabolism na barasa, aikin hanta, ko lafiya. Yawancin nufin rage illar barasa. [11]

Matsayin Gudanarwa

A cikin Amurka, ana ɗaukar DHM GRAS (wanda aka sani gabaɗaya a matsayin mai aminci) azaman ƙarin sashi. Doka ta bambanta a wasu ƙasashe. Kwararrun ilimi sun fi sanin amfani da aminci ta hanyar bayanan da ake da su. [12]

Kayan Kasuwa

Sha'awar mabukaci ga DHM na karuwa, musamman a tsakanin waɗanda ke neman daidaita yawan barasa ko tallafawa lafiyar hanta. Ana sa ran ci gaban tallace-tallace zai ci gaba tare da haɓaka bincike da wayar da kan jama'a. [13]

Suka da Rigingimu

Kamar kowane kari, DHM yana da koma baya da muhawara:

Inganci ga Tasirin Barasa

Wasu suna sukar ƙarfin shaida don ikon DHM na rage yawan buguwa ko rage yawan barasa a cikin mutane. Har yanzu ana buƙatar manyan gwaji na asibiti. [14]

Kula da lafiya

Rashin bayanan guba na ɗan adam yana sa bayanin martabar aminci na dogon lokaci na ƙarin DHM ba shi da tabbas. Wasu tambayoyi game da amfani ba tare da ƙarin bayanai ba. [15]

Jagoran masana'antu

Masu masana'anta suna jayayya da binciken da ake ciki na guba da kuma bayanan amfani da mabukaci suna goyan bayan aminci a daidaitattun allurai. Har ila yau, sun ambaci haɓaka bincike na asibiti akan inganci. [16]

Yayin alƙawarin, DHM yana buƙatar ƙarin tabbaci don tabbatar da ingantattun aikace-aikace.

Menene Dihydromyricetin Amfani Don?

Amfani na yau da kullun na DHM sun haɗa da:

- Hangos - rage ciwon kai, tashin zuciya, dizziness

- Lafiyar hanta - kare kwayoyin hanta, inganta matakan enzyme

- illar barasa - rage yawan maye, haɓaka metabolism na barasa

- tushen antioxidant - rage yawan damuwa da lalacewa

- Anti-mai kumburi - rage kumburin nama

- Cutar hanta mai kitse mara-giya - rage yawan kitse

- Detox / farfadowa na hanta - gyaran ƙwayar hanta mai motsa jiki

- Damuwa da damuwa - samar da tasirin shakatawa

Bincike ya kuma nuna yuwuwar amfani ga ciwon daji, fahimi, cututtukan ƙwayoyin cuta, ƙwayar tsoka, da ƙari. Ƙarin karatu yana tabbatar da aikace-aikace.

Menene DHM ke Yi wa Jiki?

DHM ya nuna nau'ikan tasirin halitta iri-iri:

- Yana ƙara yawan ƙwayar barasa da kuma sharewa

- Yana kare ƙwayoyin hanta ta hanyar rage yawan guba da rauni da ke haifar da barasa

- Yana aiki azaman antioxidant don rage damuwa na oxidative

- Yana nuna aikin anti-mai kumburi a cikin kyallen takarda

- Yana iya haɓaka masu karɓar GABA, yana haifar da sakamako masu annashuwa

- Ya bayyana don tallafawa aikin hanta da sabuntawa

- Abubuwan da aka gano na farko sun ba da shawarar neuroprotective, damuwa, da kuma maganin ciwon daji

Hanyoyin da ke tattare da tasirin DHM har yanzu ana kan bincike amma suna da fuskoki da yawa.

Menene Manufar DHM?

Mahimman dalilai da manufofin amfani da DHM sun haɗa da:

- Magance illar shaye-shayen barasa da ragi

- Kare hanta daga gubar barasa da lalacewa

- Taimakawa lafiyar hanta da aiki gaba ɗaya

- Samar da aikin antioxidant da anti-mai kumburi

- Inganta metabolism na barasa don saurin sharewa

- Rage damuwa, rashin barci, tashin hankali na tsoka, da zafi

- Yiwuwar hanawa da magance cututtukan da suka shafi kumburi, oxidation, lipids ko gubobi

DHM yana nuna alƙawari azaman ƙarin kariya wanda zai iya rage tasirin barasa, gubobi, da yanayi masu lahani akan lafiya.

Shin Dihydromyricetin lafiya don ɗauka?

Dangane da bayanan da ake samu, DHM ya bayyana amintacce a cikin ƙarin allurai na yau da kullun:

- Nazarin guba na dabbobi ya nuna yawan kisa mai yawa da ya wuce yawan abinci na yau da kullun. [17]

- Gwajin ɗan adam yana ba da rahoton galibi masu lahani masu sauƙi kamar bacci a mafi girman allurai. [18]

- Babu mutuwa ko munanan al'amuran da aka danganta ga ƙarin DHM.

- Gabaɗaya amincewa azaman GRAS ta hukumomin Amurka da Turai don kari. [19]

- Rahotannin anecdotal sun fi tallafawa aminci a allurai da aka ba da shawarar.

Koyaya, ana buƙatar ƙarin bayanan amincin asibiti, musamman don ɗaukar dogon lokaci. Kamar kowane kari, ana ba da shawara.

DHM Yana Taimakawa Da Hangovers?

Nazarin ɗan adam da yawa sun gano DHM yana rage tsananin rashin ƙarfi da lokacin dawowa:

- Yana rage ciwon kai, tashin zuciya, juwa, gajiya, da sauran alamomi [20]

- Yana hanzarta kawar da barasa daga jini don rage maye [21]

- Yana kare ƙwayoyin hanta kuma yana magance kumburin barasa [22]

- Yana bayyana mafi inganci lokacin sha kafin da lokacin sha

Duk da yake ba magani bane, DHM yana nuna alƙawari azaman maganin Hangover mai goyan baya. Ƙarin gwaje-gwaje na asibiti za su taimaka inganta ingantaccen aikace-aikace.

Yadda ake Amfani da DHM?

Matsakaicin masu girma dabam daga 200-500mg ana ɗaukar mintuna 30-60 kafin shan barasa. Tsawon lokacin amfani ya dogara da manufa:

- Don hangovers - Yin hidima guda ɗaya tare da barasa

- Don lafiyar hanta - 2-4 makonni gabaɗaya shawarar

- Don damuwa - Kamar yadda ake bukata, amma kada ku hada da barasa

Fara tare da ƙananan allurai kuma ƙara sannu a hankali kamar yadda aka jure. Yi magana da likitan ku kafin amfani da magunguna ko kuma idan kuna da yanayin hanta.

Kammalawa

A taƙaice, DHM fili ne na halitta mai ban sha'awa tare da dogon tarihin amfani na gargajiya. Bincike ya ci gaba da bayyana hanyoyin sa da kuma yuwuwar aikace-aikace a fannoni kamar lafiyar hanta, metabolism na barasa, da rigakafin cututtuka. Amfani da kasuwanci a cikin kari yana ƙaruwa daidai. Yayin da aka yi la'akari da aminci a daidaitattun allurai, manyan gwaje-gwajen amincin asibiti za su ba da haske mafi girma. DHM ya kasance magani mai ban sha'awa na halitta wanda ke bada garantin ƙarin bincike.

Hubei Sanxin Biotechnology Co., Ltd. ya haɗu da bincike da haɓakawa, samarwa da tallace-tallace na shekaru masu yawa. Mu ne abin dogaronku Dihydromyricetin foda dillali. Za mu iya ba da sabis na musamman azaman buƙatarku.

email: nancy@sanxinbio.com

References

[1] https://pubchem.ncbi.nlm.nih.gov/compound/Dihydromyricetin

[2] https://www.sciencedirect.com/topics/chemistry/dihydromyricetin

[3] https://www.hindawi.com/journals/jchem/2013/186028/

[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621344/

[5] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292407/

[6] https://pubmed.ncbi.nlm.nih.gov/24168342/

[7] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292407/

[8] https://pubmed.ncbi.nlm.nih.gov/25394180/

[9] https://www.mdpi.com/1420-3049/26/7/1910

[10] https://examine.com/supplements/dihydromyricetin/

[11] https://www.prnewswire.com/news-releases/dihydromyricetin-dhm-market-size-worth-195-million-by-2028-grand-view-research-inc-301220461.html

[12] https://www.frontiersin.org/articles/10.3389/fphar.2018.01157/full

[13] https://www.globenewswire.com/news-release/2021/04/15/2210861/0/en/Global-Dihydromyricetin-Market-to-Grow-at-a-CAGR-of-5-7-from-2021-to-2028.html

[14] https://www.tandfonline.com/doi/full/10.1080/10826084.2021.1875519

[15] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547601/

[16] https://www.nutraingredients-usa.com/Article/2021/06/09/Dihydromyricetin-for-liver-health-and-alcohol-overconsumption-Despite-patents-barrier-to-entry-is-low -ce-Lonza#

[17] https://pubmed.ncbi.nlm.nih.gov/32912745/

[18] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292407/

[19] https://www.frontiersin.org/articles/10.3389/fphar.2018.01157/full

[20] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292407/

[21] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983467/

[22] https://pubmed.ncbi.nlm.nih.gov/25394180/

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