Menene nicotinamide mononucleotide?

2024-01-17 14:21:43

Nicotinamide Mononucleotide (NMN) wani abu ne na yau da kullun da ke faruwa wanda ya sami babban la'akari a fagen rayuwa da jin daɗin tantanin halitta. A matsayin mafari ga nicotinamide adenine dinucleotide (NAD +), wani muhimmin coenzyme wanda ke aiki tare da tsarin tafiyar da ƙwayoyin sel daban-daban, nicotinamide mononucleotide foda yana ɗaukar wani ɓangare na gaggawa don tallafawa narkewar kuzari da kuma kiyaye iyawar tantanin halitta.

NMN wani nucleotide ne wanda aka samo daga ribose da nicotinamide. Mahimmancin ikonsa ya ta'allaka ne a cikin cikawa azaman mafari ga NAD +, tushen coenzyme don amsawar redox ta cell da ƙirƙirar kuzari. Yayin da ƙwayoyin sel suka tsufa, matakan NAD + gabaɗaya za su ragu, suna tasiri ayyukan tantanin halitta da ƙari ga tsarin balaga.

Haɗin kai tsakanin NMN da NAD+ ya haifar da binciken ƙarin NMN a matsayin dabarun da ake tsammani don taimakawa lafiyar ƙwayar cuta da yaƙi da raguwar shekaru. Nazarin bincike sun bincika tasirin ƙarin NMN akan sassa daban-daban na ilimin lissafin jiki, gami da narkewa, iyawar mitochondrial, da kuma babban tsammanin rayuwa.

Wani yanki mai ban mamaki na sha'awa shine aikin NMN a cikin samar da makamashin tantanin halitta. Ta hanyar sabunta matakan NAD +, ƙarin NMN na iya haɓaka haɓakar kuzarin tantanin halitta, yuwuwar taimakawa kyallen takarda da gabobin tare da buƙatun kuzari.

Nicotinamide Mononucleotide (NMN) yana fitowa azaman fili mai ban sha'awa tare da yuwuwar tasiri lafiyar salon salula da tsawon rai ta hanyar tallafawa matakan NAD +. Yayin da bincike ya ci gaba, zurfin fahimtar hanyoyin NMN da aikace-aikacen sa don haɓaka jin daɗin rayuwa na iya buɗewa, yana ba da sabbin ra'ayoyi kan tsufa da cututtukan da suka shafi shekaru.

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Menene nicotinamide mononucleotide mai kyau ga?

Plementarin tare da nicotinamide mononucleotide foda an nuna don taimakawa haɓaka matakan NAD +, wanda zai iya inganta haɓakar makamashi, gyaran DNA, da kunna sirtuin. Wannan ya haifar da bincikensa a matsayin mai yuwuwar rigakafin tsufa da kuma inganta lafiyar gaba ɗaya da walwala.

Adenosine triphosphate (ATP), tushen farko na makamashin salula, yana samuwa ta hanyar mitochondria, wanda ake kira "gidan wutar lantarki." Ƙarfin NMN don inganta aikin mitochondrial na iya taimakawa wajen samar da ƙarin makamashi, wanda zai iya haifar da tasiri ga aikin jiki da mahimmanci, musamman a cikin yawan mutanen da suka tsufa.

Dangantakar NMN da NAD+ haka nan ta ta'allaka ne zuwa ga haɗin gwiwarta a cikin hanyoyin gyara tantanin halitta daban-daban da tsare-tsaren kiyayewa. NAD + shine haɗin gwiwa don sirtuin-enzyme enzymes, wanda ke tsara ayyukan salula masu alaƙa da tsufa da tsawon rai. Gyaran DNA, sarrafa kumburi, da hanyoyin mayar da martani duk suna shiga tsakani ta sirtuins. Ta hanyar haɓaka matakan NAD +, NMN na iya ɗaukar motsi na sirtuins, mai yuwuwa yana tasiri juzu'in tantanin halitta da tsawon rayuwa.

Bugu da kari, NMN mai yiwuwa yana shafar yanayin da suka shafi shekaru. Bincike ya ba da shawarar cewa ƙarin NMN na iya yanke shawarar yin tasiri ga lafiyar zuciya da jijiyoyin jini, gami da haɓaka ƙarfin jijiya da rage karfin iskar oxygen. Bugu da ƙari, an yi nazarin tasirin neuroprotective na NMN a cikin mahallin cututtukan neurodegenerative, tare da wasu shaidun da ke nuna yiwuwar hakan.

Yayin jarrabawar a kan Nicotinamide mononucleotide foda mai girma yana da alƙawarin, yana da mahimmanci a lura cewa filin yana ci gaba har yanzu, kuma ana sa ran ƙarin bincike don gano cikakken tasirin da aka zayyana, ingantattun allurai, da yuwuwar sakamakon ƙarin NMN. Kafin shigar da NMN cikin al'adar mutum, yana da kyau a tuntuɓi ƙwararrun kiwon lafiya, kamar yadda yake tare da kowane ƙarin abinci mai gina jiki.

Shin NMN kawai bitamin B3?

Nicotinamide Mononucleotide shine mafari ga nicotinamide adenine dinucleotide (NAD+), tushen coenzyme don narkewar kuzarin tantanin halitta da kuma yanayin hawan jini daban-daban. Iyalin B-na gina jiki sun haɗa niacin, in ba haka ba ana kiranta bitamin B3, wanda za'a iya canza shi zuwa NMN a cikin jiki ta hanyoyi marasa ma'ana. Ko da yake NMN da niacin suna raba wasu kamanceceniya, NMN shine mafarin haɗin kai na NAD+ nan take.

Ee, ana iya yin NMN a cikin sel daga nicotinic acid da nicotinamide, duka nau'ikan niacin. A kowane hali, gudanar da NMN nan da nan a matsayin haɓakawa yana ɗaukar hanya mafi ƙira da inganci don taimakawa matakan NAD +. Wannan ya haifar da binciken NMN a matsayin sasanci da ake tsammani a cikin hanyoyin da suka shafi tsufa da kuma yanayin da ke da alaƙa.

Yayin da aka samo NMN daga bitamin B3 (niacin), yana da mahimmanci a lura cewa ba daidai ba ne. NMN wani nucleotide ne, yayin da bitamin B3 ke yin nuni ga taron gauraye da suka haɗa niacin (nicotinic corrosive) da niacinamide (nicotinamide). Ɗaya daga cikin kwayoyin da za a iya yin a cikin jiki lokacin da niacinamide ya canza shine NMN.

Kodayake duka NMN da bitamin B3 na iya ƙarawa zuwa ƙirƙirar NAD +, NMN yana da la'akari da la'akari da shi don iyawarsa don haɓaka matakan NAD + kai tsaye, yana mai da shi yuwuwar yuwuwar aikace-aikacen gyarawa. Gabaɗaya, yayin da NMN ke ba da haɗin gwiwa tare da bitamin B3, wani fili ne marar kuskure tare da ayyuka na musamman a cikin lafiyar tantanin halitta, musamman a matsayin mai gaba ga haɗakar NAD +. A cikin neman hanyoyin da ke haɓaka tsawon rai da jin daɗin rayuwa gaba ɗaya, bincika abubuwan da za su iya amfani da su Nmn nicotinamide mononucleotide foda a cikin tsufa da yanayin da suka shafi shekaru suna wakiltar hanya mai ban sha'awa.

Ta yaya NMN zai iya zama da amfani ga lafiya?

NMN ta kasance batun bincike daban-daban da ke bincika yuwuwar fa'idodin lafiyarta. Wasu fa'idodin da ke da alaƙa da ƙarin NMN sun haɗa da:

1. Illar Maganin Tsufa: NMN na iya taimakawa inganta tsufa mai kyau ta hanyar tallafawa metabolism na makamashin salula da hanyoyin gyaran DNA. An samo shi don kunna sirtuins, rukuni na sunadaran da ke hade da tsawon rai da lafiya.

2. Lafiyar Jiki: NMN ya nuna sakamako mai ban sha'awa a cikin haɓaka metabolism na glucose da kuma insulin hankali a cikin nazarin dabbobi. Yana iya taimakawa wajen daidaita metabolism na makamashin salula kuma yana ba da gudummawa ga lafiyar lafiyar jiki gaba ɗaya.

3. Kariyar Neuro: Ragewar NAD + yana da alaƙa da cututtukan neurodegenerative masu alaƙa da shekaru. Ƙarin NMN ya nuna tasirin neuroprotective a cikin ƙididdiga na asali, yana nuna yiwuwar amfani da shi a cikin rigakafi ko maganin irin waɗannan yanayi.

Hubei Sanxin Biotechnology Co., Ltd. ya haɗu da bincike da haɓakawa, samarwa da tallace-tallace na shekaru masu yawa. Mu ne abin dogaronku nicotinamide mononucleotide foda dillali. Za mu iya ba da sabis na musamman azaman buƙatarku.

email: nancy@sanxinbio.com

References:

  1. Yoshino J, Baur JA, Imai S. NAD + masu tsaka-tsaki: ilimin halitta da yiwuwar warkewa na NMN da NR. Cell Metab. 2018;27 (3): 513-528.

  2. Canto C, Houtkooper RH, Pirinen E, et al. NAD (+) precursor nicotinamide riboside yana haɓaka metabolism na oxidative kuma yana ba da kariya daga kiba mai kitse da ke haifar da kiba. Cell Metab. 2012;15 (6): 838-847.

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