An Sami Sabon Ci gaba a cikin Tsarin Tsarin Intestinal Flora Ta Astragalus Polysaccharides

2023-08-14 09:37:51

Kwanan nan, Desulfovibrio Vulgaris (Desulfovibrio Vulgaris), wani babban tasiri acetic acid samar da kwayoyin cuta, an buga online a cikin kasa da kasa mujallar Microbiology ta Gut Microbes (District 1). Kwayar da ke haifar da acetic acid mai ƙarfi, tana rage cutar hanta mai kitse marar giya a cikin beraye.

Ciwon hanta mai ƙiba (NAFLD) wanda ba shi da barasa ba shine mafi yawan cututtukan hanta na yau da kullun, kuma a halin yanzu akwai ƙarancin magunguna masu inganci. Yawancin karatu sun nuna cewa rashin lafiyan microbiota na hanji shine muhimmin mahimmanci a cikin cututtukan cututtukan cututtukan da ke tushen kiba. Sabili da haka, ana ɗaukar ƙa'idar microbiota na hanji a matsayin muhimmiyar sabuwar dabara don rigakafi da magance cututtukan rayuwa.

Polysaccharides wani nau'i ne na mahaɗan macromolecular na halitta da aka rarraba a cikin magungunan gargajiya na kasar Sin. Yawancin karatu sun nuna cewa polysaccharides na shuka yana da tabbataccen tasiri akan tsarin metabolism, amma ainihin hanyar ba ta bayyana gaba ɗaya ba. Ƙungiyar Houkai Li ta nuna a cikin binciken da ya gabata cewa astragalus membranaceus polysaccharides, babban tasiri mai tasiri na astragalus membranaceus, zai iya inganta kiba da NAFLD, kuma sun lura da tasirin ASTRagalus membranaceus polysaccharides akan tsire-tsire na hanji da kuma metabolites ta hanyar metagenomic hade tare da nazarin metabonom. Hasashen axis na "magunguna-hanji microbiota - metabolite - mai watsa shiri metabolism" an gabatar da shi don inganta haɓakar NAFLD ta APS.

Dangane da wannan hasashe na kimiyya, ƙungiyar binciken ta binciki takamaiman ƙwayoyin cuta na hanji da abubuwan da ke da alaƙa da APS ke tsara su ta hanyar dabarun haɗin gwiwar multi-omics, kuma sun gano cewa haɓakar NAFLD ta APS ba wai kawai yana da halaye na dogaro da flora ba, har ma yana iya haɓaka haɓakar hanji sosai. kwayoyin cuta (Desulfovibrio Vulgaris). Ci gaba da karatu ya tabbatar da cewa kwayar cutar ba kawai mai samar da H2S ba ne, amma kuma tana da ingantaccen ikon samar da acetic acid. Exogenous kari na wannan kwayan cuta muhimmanci inganta hanta steatosis, insulin hankali da kuma nauyi riba a cikin berayen ciyar da wani babban mai mai rage cin abinci. Ta hanyar bincike na hanta RNA SEQ da nazarin nazarin halittu, an tabbatar da cewa inganta NAFLD yana da alaka da hana hanta FASN da CD36 furotin. Wannan binciken ya ba da sababbin shaidu don bayyana tsarin APS don inganta NAFLD, kuma ya ba da bayani don bincika tsarin APS a cikin daidaita yanayin flora na hanji da inganta haɓakar ƙwayoyin cuta tare da taimakon fasahar multiomics.

Tawagar Farfesa Ding Kan daga Cibiyar Nazarin Materia Medica ta Shanghai, Cibiyar Kimiyyar Kimiyya ta kasar Sin, ta taimaka wajen nazarin abubuwan da ake amfani da su na astragalus polysaccharide monosaccharide a cikin wannan binciken. zuwa Jami'ar Shanghai Jiao Tong. Ningning Zheng da Wei Jia sune mawallafin wannan takarda. Hong Ying, dan takarar digiri na uku na kungiyar Farfesa Li Houkai, shi ne marubucin farko na wannan takarda, kuma jami'ar likitancin gargajiya ta Shanghai ita ce ta farko da ta sanya hannu kan takardar. Gidauniyar binciken kimiyyar dabi'a ta kasar Sin ce ta dauki nauyin binciken.