CoQ10 wani fili ne da jiki ke samarwa a zahiri wanda ke da mahimmanci don samar da makamashin tantanin halitta kuma yana aiki azaman antioxidant mai ƙarfi. Matakan CoQ10 a cikin jiki suna raguwa tare da shekaru. Kodan na buƙatar makamashi mai mahimmanci kuma suna da haɗari ga danniya na oxidative, yana sa su iya lalacewa a kan lokaci.

Ganin mahimman ayyuka na CoQ10, masu gwaji sun yi bincike ko Coenzyme Q10 kari zai iya taimakawa wajen ba da odar lafiya da aikin rufe oda, musamman a cikin mutanen da ke da gunaguni na al'ada ko cututtukan da ke da alaƙa kamar ciwon sukari. Wannan abun da ke ciki zai ba da bayyani na bincike na yanzu na CoQ10 da oda lafiya.

Matsayin CoQ10 a Lafiyar Koda

CoQ10 yana aiki sosai a cikin mitochondria tantanin halitta, makamashin makamashi na sel. A matsayin mai ɗaukar lantarki a cikin sarkar numfashi na mitochondrial, CoQ10 yana taimakawa haɓaka haɗin ATP da samar da makamashi. Kodan suna da buƙatun makamashi mai yawa da abubuwan mitochondria masu yawa, suna yin CoQ10 mahimmanci don aikin su.

CoQ10 kuma yana aiki azaman antioxidant mai amsa lipid wanda zai iya rufe membranes cell da lipoproteins daga lalacewar oxidative. Danniya na Oxidative shine babban mai ba da gudummawa don yin odar rauni. CoQ10 na iya taimakawa wajen rage kumburi da fibrosis a cikin gashin fuka-fukan ta hanyar yin watsi da masu juyin juya hali na kyauta.

Bugu da ƙari kuma, an gano matakan CoQ10 sun kasance da ƙananan ƙananan marasa lafiya tare da ciwon koda na kullum idan aka kwatanta da mutane masu lafiya. Mayar da matakan CoQ10 na salula na iya inganta lafiyar koda da aiki.

Bayanin Yanayin Koda

Wasu yanayi na yau da kullun waɗanda ke shafar lafiyar koda sun haɗa da:

- Ciwon koda na yau da kullun - raguwar aikin koda a hankali akan lokaci.

- ciwon sukari nephropathy - lalacewar koda da ciwon sukari ke haifarwa. Babban rikitarwa na ciwon sukari.

- Ciwon koda - matsananciyar ajiya da ke tasowa a cikin koda.

- Ciwon koda na polycystic - kodan suna haɓaka ta hanyar cysts masu cike da ruwa. Rashin gado.  

- Ciwon Nephrotic - kodan suna fitar da furotin da yawa a cikin fitsari.

- Ciwon fitsari - cututtuka na kwayoyin cuta na kowane bangare na tsarin fitsari.

Bincike ya nuna cewa ƙarar CoQ10 na iya taimakawa wajen rage ci gaban wasu cututtuka na koda ta hanyar rage damuwa na oxidative, kumburi, da fibrosis. Ana buƙatar ƙarin nazarin ɗan adam.

Binciken Bincike da Hujjoji da ake da su

Duk da yake sakamakon gabaɗaya yana da alƙawarin, har yanzu ana buƙatar manyan binciken bincike don tabbatar da ingancin CoQ10 don tallafawa lafiyar koda a cikin mutane.

Gano Bincike mai mahimmanci

- Nazarin dabba ya nuna ƙarin CoQ10 yana rage raunin koda da fibrosis yayin da inganta yanayin antioxidant da aikin mitochondrial.

- Wasu nazarin ɗan adam sun nuna cewa matakan CoQ10 sun ragu sosai a cikin marasa lafiya na koda na yau da kullun ba su kan dialysis ba idan aka kwatanta da sarrafawa.

- Ƙananan ƙananan nazarin ɗan adam sun ba da rahoton cewa ƙarin CoQ10 na iya inganta aikin koda kuma ya rage proteinuria a cikin cututtukan koda na kullum.

- A cikin marasa lafiya na hemodialysis, binciken daya ya ruwaito cewa CoQ10 ya jinkirta ci gaban atherosclerosis a cikin shekaru 2.

- Ɗaya daga cikin binciken a cikin masu ciwon sukari ya gano cewa CoQ10 ya rage raguwar aikin koda a cikin shekara 1.

- Ba duk binciken da aka samu a fili fa'ida na CoQ10 kari a kan daidaitattun ayyukan koda kamar GFR.

- Babu wani babban tasiri da aka ruwaito tare da ƙarin CoQ10 a cikin binciken koda har zuwa yau.

Duk da yake samfuran dabbobi a fili suna nuna tasirin kariya na koda na CoQ10, ana buƙatar ƙarin ƙarin nazarin ɗan adam don tabbatar da fa'idodi akan sigogi kamar raguwar GFR, proteinuria, da dogaro na dialysis.

Hanyoyi masu yuwuwar Aiki

Wasu hanyoyin da aka tsara wanda CoQ10 zai iya amfana da kodan sun haɗa da:

- Inganta samar da mitochondrial ATP a cikin ƙwayoyin koda waɗanda ke da buƙatun makamashi mai yawa. Wannan na iya haɓaka aikin koda.

- Rage lalacewar oxidative ga lipids, sunadarai, da DNA a cikin nama na koda ta hanyar lalata nau'in iskar oxygen mai amsawa azaman antioxidant. Damuwar Oxidative yana haifar da raunin koda.

- Kashe hanyoyin kumburi, apoptosis, da fibrosis waɗanda ke haifar da lalacewar ƙwayoyin koda da mutuwa.

- Kare endothelium da rage jinkirin ci gaban atherosclerosis a cikin vasculature na koda don kiyaye kwararar jini.

- Inganta ingancin sauran antioxidants kamar bitamin E. CoQ10 yana sake yin amfani da shi kuma yana sake farfado da bitamin E.

- Mai yuwuwar rage matakan hawan jini ta hanyar rage juriya na gefe, kyale mafi kyawun bugun koda.

Har yanzu ana buƙatar ƙarin karatun asibiti don tabbatar da waɗannan hanyoyin dabarun fassara zuwa ingantaccen ingantaccen aikin koda da sakamakon lafiya.

Kariya da Shawarwari

Lokacin la'akari da CoQ10 don lafiyar koda, kiyaye waɗannan ka'idoji a zuciya:

- Tuntuɓi likitan ku kafin shan CoQ10, musamman idan kuna da yanayin koda ko kuma kuna kan dialysis, saboda ana iya buƙatar gyaran sashi.

- Kula da aikin koda tare da gwaje-gwajen gwaje-gwaje kamar yadda likitanku ya ba da shawarar. Bayar da rahoton kowane canje-canje.

- Sha isassun ruwa kuma bi ka'idodin abinci don tallafawa lafiyar koda gabaɗaya.

- Nemo samfuran ƙarin samfuran suna waɗanda ke ba da nau'in aiki na CoQ10 da ake kira ubiquinol.

- Ba CoQ10 aƙalla watanni 3-6 don cimma sakamako mafi kyau na koda a daidaitattun allurai.

- Haɗa CoQ10 tare da sauran antioxidants kamar bitamin C, bitamin E, da ALA don ƙarin fa'idodi.

- Bincika yiwuwar hulɗar miyagun ƙwayoyi idan hada CoQ10 tare da hawan jini ko magungunan ciwon sukari.

Karkashin jagorancin likita, CoQ10 yana fitowa a matsayin amintaccen ƙarin tallafi don lafiyar koda, amma ana buƙatar ƙarin bincike don daidaita ƙa'idodi masu inganci. Ana ba da shawarar kula da aikin koda.

Ta yaya CoQ10 ke shafar zuciya da koda?

CoQ10 yana amfanar duka zuciya da kodan musamman ta hanyar haɓaka samar da makamashi ta salula, kawar da radicals kyauta, da rage lalacewar iskar oxygen. Zuciya da kodan suna da buƙatun kuzari sosai kuma suna da saurin kamuwa da damuwa. CoQ10 yana tallafawa metabolism na makamashi a cikin mitochondria cell na zuciya da koda. A matsayin antioxidant, CoQ10 kuma yana kare ƙwayoyin zuciya da koda daga lalacewa mai lalacewa mai lalacewa. Wasu shaidu sun nuna cewa CoQ10 na iya taimakawa wajen rage karfin jini. Tsayawa mafi kyawun matakan CoQ10 na iya taimakawa wajen tallafawa lafiyar waɗannan mahimman gabobin. Koyaya, har yanzu ana buƙatar manyan karatu.

Me yasa likitoci basu bada shawarar CoQ10 ba?

Akwai 'yan dalilan da ya sa CoQ10 kari na iya zama ba a kai a kai shawarar da duk likitoci:

- Har yanzu ana buƙatar gwaji mafi girma na asibiti don tabbatar da tasirin warkewa a cikin ɗan adam. Shaida tana da iyaka.

- Mafi kyawun dabarun yin allurai don takamaiman yanayi ba a sani ba.

- Madaidaitan ƙa'idodin ƙa'idodi ba su haɗa da CoQ10 ba saboda ƙarancin shaida.

- Wasu likitoci na iya fi son mayar da hankali kan magunguna da canje-canjen salon rayuwa tare da ingantaccen inganci.

- Ƙa'idar kari ta rasa, yana ƙara damuwa game da kula da inganci da daidaito a cikin lakabi.

- Bayanan aminci na dogon lokaci a cikin yawan jama'a yana da iyaka.

- CoQ10 ba a rufe shi da inshora, yana sa farashi ya zama shinge mai yuwuwa.

Koyaya, halaye suna canzawa yayin da ƙarin gwaji na sarrafawa suka fito. Wasu masu aikin gaba-gaba suna ba da shawarar ƙarin CoQ10 don wasu yanayi, musamman lokacin da matakan suka yi ƙasa. Koyaya, ƙarin bincike da ƙa'ida har yanzu ana buƙatar gabaɗaya don karɓu na yau da kullun.

Wanene bai kamata ya ci CoQ10 ba?

Ana ɗaukar kariyar CoQ10 mai aminci ga yawancin mutane a daidaitattun allurai. Koyaya, wasu mutane yakamata suyi taka tsantsan tare da amfani da CoQ10:

- Mata masu ciki ko masu shayarwa, tunda bayanan amfani sun iyakance.

- Mutanen da aka shirya yi wa tiyata a cikin makonni 2 masu zuwa, kamar yadda CoQ10 na iya rage jinin dan kadan.

- Mutanen da ke shan maganin hana jini kamar warfarin, kamar yadda CoQ10 na iya ƙara haɗarin zubar jini. Ana ba da shawarar kusancin sa ido kan yanayin coagulation na jini idan ana amfani da duka biyun.

- Mutanen da ke fama da cutar hanta ko gazawa, kamar yadda hanta ke shiga cikin haɗin gwiwar CoQ10.

- Yara, saboda rashin bayanan aminci.

- Mutanen da ke fama da cutar sankara ko ciwon nono, tunda ana buƙatar ƙarin bincike kan tasirin CoQ10 akan waɗannan cututtukan.

- Mutanen da ke da coenzyme Q10 hyperoxaluria, yanayin gado mai wuya.

Duk wanda ke da mahimman yanayin kiwon lafiya ya kamata ya tuntuɓi likitan su kafin ya ƙara CoQ10 don takamaiman jagora.

Menene alamun buƙatar CoQ10?

Babu takamaiman alamun bayyanar da koyaushe suna nuna buƙatar ƙarin CoQ10. Koyaya, wasu alamun rashi na CoQ10 sun haɗa da:

- Gajiya, rauni, ko rage jurewar motsa jiki.

- Ciwon tsoka, zafi ko maƙarƙashiya.

- Yin amfani da magungunan statin. Statins sun ƙare CoQ10.

- Alamomin jijiya kamar rawar jiki, juwa, ko ciwon kai.

- Hawan jini.

- Rashin ciwon zuciya.

- Ciwon mitochondrial.

- Cututtukan koda kamar ciwon koda na yau da kullun.

- Matsalar rashin haihuwa ga maza ko mata.

- Rashin hankali ko cututtukan neurodegenerative.

Gwajin matakan jini na CoQ10 na iya tabbatar da ƙarancin matsayi na asibiti. Koyaya, da yawa tare da matakan CoQ10 na al'ada har yanzu suna samun fa'idodi daga kari. Wadanda abin ya shafa yakamata su tattauna gwaji da kari tare da likitan su.

Wanne ya fi kyau ga CoQ10 na zuciya ko man kifi?

Dukansu CoQ10 da man kifi suna amfana da lafiyar zuciya, amma ta hanyoyi daban-daban. Zanen kifin kifi yana samar da omega-3-3 fats EPA da DHA, wanda ke rage kumburi, ƙananan triglycerides, kuma yana iya inganta al'amuran zuciya da jijiyoyin jini. CoQ10 yana haɓaka samfuran makamashin salula, yana aiki azaman antioxidant, kuma yana taka muhimmiyar rawa a cikin metabolism na ƙwayar zuciya. Don cikakkiyar goyon bayan lafiyar zuciya, waɗannan biyun sun bayyana ma'amala. Wasu nazarin suna amfani da man kifi da kuma CoQ10. Mafi kyawun sakamako na zuciya na iya buƙatar isasshen abinci na EPA/DHA da CoQ10. Ga majinyata masu haɗari ko waɗanda ke da cututtukan zuciya, ana ba da shawarar shigar da likita akan mafi kyawun amfani da abubuwan kari biyu.

Kammalawa

A taƙaice, CoQ10 yana nuna babban alƙawari don tallafawa lafiyar koda da aiki dangane da muhimmiyar rawar da yake takawa a cikin makamashin makamashi da ayyukan antioxidant. Nazarin kwayar halitta da dabba suna bayyana tasirin kariya na koda. Ƙananan binciken ɗan adam yana ba da rahoton fa'idodi a cikin cututtukan koda na yau da kullun, ciwon sukari nephropathy, da marasa lafiya na dialysis. Koyaya, ana buƙatar ƙarin tsauraran gwaje-gwaje na asibiti tare da ingantattun ka'idoji, musamman game da sashi, tsawon lokaci, da sakamako. Yi aiki tare da likitan nephrologist don jagora lokacin amfani da CoQ10 don lafiyar koda. Yayin da yake da ƙarancin illa, yi taka tsantsan tare da kowane yanayi na likita ko magunguna. Bincike ya ci gaba da fitowa, amma CoQ10 a matsayin magani mai mahimmanci ya bayyana ma'ana ga wasu mutane da ke neman haɓaka aikin koda da jinkirin ci gaban cutar. Gwaje-gwaje masu girma na iya ba da ƙarin tabbataccen shaida nan ba da jimawa ba.

Hubei Sanxin Biotechnology Co., Ltd. ya haɗu da bincike da haɓakawa, samarwa, da tallace-tallace na shekaru masu yawa. Mu ne abin dogaronku Coenzyme Q10 dillali. Za mu iya samar da ayyuka na musamman kamar yadda kuka nema.

email: nancy@sanxinbio.com

References

1. Aminzadeh, MA, & Vaziri, ND (2018). Rage ƙa'idar jigilar jigilar lantarki ta mitochondrial a cikin cututtukan koda na yau da kullun. Kidney International, 94 (2), 258-266. doi.org/10.1016/j.kint.2018.02.013

2. Yeung, CK, Billings, FT, Claes, D., Roshanravan, B., Roberts, LJ, Himmelfarb, J., Ikizler, TA, & Group, C.-TS (2015). Coenzyme Q10 nazarin-haɓaka kashi-kashi a cikin marasa lafiya na hemodialysis: aminci, haƙuri, da tasiri akan danniya oxidative. BMC nephrology, 16, 183. https://doi.org/10.1186/s12882-015-0173-4

3. Hodroge, A., Drozdz, M., Smani, T., Hemmeryckx, B., Rawashdeh, A., Avkiran, M., & Amoui, M. (2021). Sakamakon kariya na coenzyme Q10 akan nephropathy na ciwon sukari: nazari na yau da kullun na in vitro da nazarin vivo. Biomolecules, 11 (8), 1166. https://doi.org/10.3390/biom11081166

4. Ivanov VT et al. (2017) Sakamakon micro watsar da tsarin Coenzyme Q10 akan statin-related myopathy bayyanar cututtuka a cikin marasa lafiya da ciwon sukari: Gwajin da bazuwar, Dokokin Endocrine, 51: 4, 206-212, DOI: 10.1515 / enr-2017-0026

5. Mortensen SA et al (2014). Coenzyme Q10: fa'idodin asibiti tare da haɓakar ƙwayoyin halitta suna ba da shawarar ci gaban kimiyya a cikin kula da cututtukan zuciya na yau da kullun, Jarida ta Duniya na Cardiology, 175: 3, 56-61. doi.org/10.1016/j.ijcard.2014.05.011.

6. Yeung, CK, Billings, FT, Claes, D., Roshanravan, B., Roberts, LJ, Himmelfarb, J., Ikizler, TA, & Group, C.-TS (2016). Coenzyme Q10 kashi na haɓaka binciken haɓakawa a cikin marasa lafiya na hemodialysis: aminci, haƙuri, da tasiri akan damuwa na oxidative. BMC nephrology, 17, 64. https://doi.org/10.1186/s12882-016-0257-y

7. Zhang, Y., Wang, L., Zhang, J., Xi, T., LeLan, F., & Li, Z. (2020). Tasirin Coenzyme Q10 akan Marasa lafiya Tare da Nephropathy na Ciwon sukari: Nazarin Meta na Gwajin Sarrafa Bazuwar. Iyakoki a cikin ilimin harhada magunguna, 11, 108. https://doi.org/10.3389/fphar.2020.00108